{"id":9052,"date":"2026-11-08T13:28:39","date_gmt":"2026-11-08T13:28:39","guid":{"rendered":"https:\/\/zamzam.edu.sd\/2026\/?page_id=9052"},"modified":"2026-11-08T15:56:23","modified_gmt":"2026-11-08T15:56:23","slug":"senolytic-clearance-of-chemotherapy-induced-senescence-as-an-anti-relapse-strategy-zamzam-medical-journal","status":"publish","type":"page","link":"https:\/\/zamzam.edu.sd\/2026\/?page_id=9052","title":{"rendered":"Senolytic Clearance of Chemotherapy-Induced Senescence as an Anti-Relapse Strategy \u2013 Zamzam Medical Journal"},"content":{"rendered":"

\u2b07 Download Article PDF (pp. 5\u20138)<\/a><\/p>\n

\n

Abstract<\/p>\n

Genotoxic chemotherapy kills proliferating tumor cells but also drives a substantial fraction of surrounding stromal and normal cells into senescence, a permanently arrested but metabolically active state. Senescent cells secrete a senescence-associated secretory phenotype (SASP), a cocktail of pro-inflammatory cytokines, chemokines, and matrix-remodeling enzymes that actively contributes to chemotherapy side effects and, critically, can reactivate dormant disseminated tumor cells and promote cancer relapse. This paper synthesizes a decade of evidence: from the original identification of senolytic drugs (compounds that selectively clear senescent cells) through direct demonstration that senolytic clearance reduces cancer relapse and metastasis in mice, to a completed first-in-human senolytic trial and a 2025 mechanistic study directly linking chemotherapy-induced senescence to neutrophil extracellular trap (NET)-mediated reactivation of dormant breast cancer cells. Because the leading senolytic combination (dasatinib plus quercetin) uses two agents already in clinical use \u2014 an approved oncology drug and a well-tolerated flavonoid \u2014 this represents an unusually mature repurposing opportunity: the missing step is not drug discovery but a dedicated oncology trial testing senolytic administration in the peri-chemotherapy window as a relapse-prevention strategy. We present the mechanistic cascade, tabulate the evidence timeline, and propose a general intervention framework and trial design.<\/p>\n

Keywords:<\/strong> cellular senescence; SASP; senolytics; dasatinib; quercetin; neutrophil extracellular traps; tumor dormancy; cancer relapse<\/p>\n

Authors:<\/strong> Khalid Omer Alfarouk, PhD<\/p>\n

Affiliation:<\/strong> Zamzam University College, Khartoum, Sudan<\/p>\n

Accepted: 29 September 2026 \u00b7 Published: 6 October 2026 \u00b7 Vol. 1, Issue 2 \u00b7 pp. 5\u20138<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2b07 Download Article PDF (pp. 5\u20138) Abstract Genotoxic chemotherapy kills proliferating tumor cells but also drives a substantial fraction of surrounding stromal and normal cells into\u2026<\/p>\n","protected":false},"author":27,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9052","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9052"}],"version-history":[{"count":7,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9052\/revisions"}],"predecessor-version":[{"id":9217,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9052\/revisions\/9217"}],"wp:attachment":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}