{"id":9054,"date":"2026-11-08T13:28:50","date_gmt":"2026-11-08T13:28:50","guid":{"rendered":"https:\/\/zamzam.edu.sd\/2026\/?page_id=9054"},"modified":"2026-11-08T15:56:23","modified_gmt":"2026-11-08T15:56:23","slug":"albendazole-as-sole-treatment-for-cystic-echinococcosis-genotype-6-in-central-sudan-rct-protocol-zamzam-medical-journal","status":"publish","type":"page","link":"https:\/\/zamzam.edu.sd\/2026\/?page_id=9054","title":{"rendered":"Albendazole as Sole Treatment for Cystic Echinococcosis Genotype 6 in Central Sudan: RCT Protocol \u2013 Zamzam Medical Journal"},"content":{"rendered":"

\u2b07 Download Article PDF (pp. 9\u201311)<\/a><\/p>\n

\n

Abstract<\/p>\n

Cystic echinococcosis (CE), caused by Echinococcus granulosus, is a neglected zoonotic disease with an estimated global economic burden of 3 billion US dollars annually and a documented prevalence of 1.04% among adults in central Sudan, where Genotype 6 \u2014 the camel strain \u2014 predominates. The established standard of care pairs surgical or percutaneous intervention (PAIR) with six months of adjuvant albendazole, a regimen that is expensive, technically demanding, and carries hepatotoxic risk requiring serial liver-function monitoring. A pilot study by our group in which six patients with hepatic CE were treated with albendazole monotherapy achieved a 100% cure rate at two-year follow-up, providing the rationale for a controlled trial. We present the protocol for the first randomized, double-blind, placebo-controlled trial of albendazole as sole therapy for hepatic CE Genotype 6. Ninety patients will be identified through a mobile-ultrasound survey of 12,000 adults in central Sudan and randomized 1:1 to albendazole or placebo for twelve weeks.<\/p>\n

Keywords:<\/strong> cystic echinococcosis; hydatid disease; albendazole; Sudan; randomized controlled trial; Echinococcus granulosus; Genotype 6; PAIR; molecular genotyping<\/p>\n

Authors:<\/strong> Mohamed Ahmed Ismail, MD, PhD<\/p>\n

Affiliation:<\/strong> Zamzam University College, Khartoum, Sudan<\/p>\n

Accepted: 29 September 2026 \u00b7 Published: 6 October 2026 \u00b7 Vol. 1, Issue 2 \u00b7 pp. 9\u201311<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2b07 Download Article PDF (pp. 9\u201311) Abstract Cystic echinococcosis (CE), caused by Echinococcus granulosus, is a neglected zoonotic disease with an estimated global economic burden of\u2026<\/p>\n","protected":false},"author":27,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9054","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9054"}],"version-history":[{"count":7,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9054\/revisions"}],"predecessor-version":[{"id":9218,"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=\/wp\/v2\/pages\/9054\/revisions\/9218"}],"wp:attachment":[{"href":"https:\/\/zamzam.edu.sd\/2026\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}