zamzam University College (ZUC) Congratulate
النسخة العربية
Date and Place of birth
August 13th, 1983; Omdurman, Sudan
Marital Status
Married
2. Education:
• Ph.D. in Molecular Pharmacology, 2015
University of Khartoum
Khartoum, Sudan
H. Lee Moffitt Cancer Center
Tampa, Florida, USA
• M. Pharm, 2011
University of Khartoum
Khartoum, Sudan
• B. Pharm, 2005
Faculty of Pharmacy
University of Khartoum
Khartoum, Sudan
3. Research Specialty:
3.1 Evolution and Ecology of Cancer:
• Tumor colony consists of heterogeneous populations (diversity) due to differences in local resources and the spatial distribution of cells around tumor blood vessels. Diversity is passed down to future generations. In certain conditions, e.g., administering chemotherapy, the population density is altered, and the selection of resistant traits occurs. Due to diversity, inheritance, and fitness, carcinogenesis is an ongoing, adaptive evolutionary process.
• Carcinogenesis is the process by which some tumor cells succeed in growth and colonization. Tumorigenesis is equivalent to ecological success. Tumor metastases occur due to (I) maintaining population density as improving the entire population fitness and (II) population (species) distribution. Ecological succession and dispersal represent tumors as an ecosystem. The current research focuses on developing novel pharmacological approaches to restore the initial primary (regular) habitat and thus prevent tumor cell evolution.
3.2 Tumor Metabolism:
• Typically, glucose is utilized in two parts inside the cells: glycolysis which occurs within the cytoplasm, and the Krebs cycle (Tri-Carboxylic Acid Cycle) in the presence of oxygen. Tumor cells up-regulate the glycolytic pathway even in the presence of oxygen. This phenomenon, termed the “Warburg Effect,” is a hallmark of cancer. The current work is to understand the metabolic changes accompanying the evolution of resistance to chemotherapy.
• Cancer cells have unique metabolic systems by deactivating Krebs’ cycle and upregulation of cytoplasmic utilization of glucose. Therefore, alteration of mitochondrial metabolism is a hallmark of cancer (Warburg-Effect). Restoration of mitochondrial function might represent a significant step in managing cancer. On the contrary, activation of Krebs’ cycle is associated with some neurodegenerative diseases. Therefore, I am leading a research facility in mitochondrial biology and pharmacology, fine-tuning mitochondria to manage cancer and preventing neurodegenerative diseases.
3.3 The human genome – Microbiome interactions:
• To study the dynamic of the human genome, one must study the human genome from parents, plus microorganisms’ genome (bacteria, viruses, protozoa) that harbors them within the gut and other areas (microbiome). I am an expert in analyzing the molecular ecology of the human genome – microbiome interactions and designing therapeutics strategies gain benefit humans with the effect on the human ecosystem or at least minimizing the detrimental impact upon altering the microorganismal habitat, e.g., we are studying the role of Helicobacter pylori in its possible correlation with gastric cancer. Eradication of H. pylori will prevent gastric cancer but will develop esophageal adenocarcinoma. Therefore, it is a conundrum. The collaborators and I developed a novel model that treats H.pylori without affecting esophageal adenocarcinoma through instigation and correction of the redox state of the human body.
4. Publications:
Link for Google Scholar
